Which of the following drug / target molecule pairs is incorrect with respect to anticoagulation therapy?
Nonspecific
Medicine (illnesses/therapeutics)
No
U
C
Of the pairs, (C) is incorrect.
Warfarin (Coumadin) = decreases blood clotting by blocking Vitamin K Epoxide Reductase, an enzyme that that reactivates Vitamin K. Without an abundance of free/active Vitamin K, clotting factors II, VII, IX, and X are not activated, therefore decreasing clotting ability. Of note, administering Vitamin K is the reversal agent for Coumadin's effect.
An inhibition of factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting thrombin formation.
Citation:
Morgan Jr, JH (2013). Perioperative prophylaxis for deep vein thrombosis (Ch. 9). In J.T. Southerland(Ed) McGlamry’s Comprehensive Textbook of Foot and Ankle Surgery, 4thEd. (pp. 97 – 100). Philadelphia, Pennsylvania: Wolters Kluwer Health |Lippincott Williams & Wilkins.
Photo credit by Wikipedia Commons (Coagulation full)
Photo credit by Wikipedia Commons (Coagulation full)
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